Lamp2b是什么蛋白

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August undefined, 2024

TīmeklisSynthetic peptide corresponding to Human LAMP2B aa 350 to the C-terminus (C terminal) conjugated to keyhole limpet haemocyanin. LAMP2 has 3 distinct isoforms, … Tīmeklis2024. gada 18. marts · LAMP2B is the predominant isoform expressed in cardiomyocytes. This study evaluates the efficacy of human LAMP2B gene transfer …

Systemic AAV9.LAMP2B injection reverses metabolic and ... - Science

http://www.biofeng.com/adjy/zhili/pcDNA%20GNSTM-3-RVG-10-Lamp2b-HA.html Tīmeklis2024. gada 21. marts · LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with LAMP2 include Danon Disease and … u know nothing jon snow

Frontiers The Lysosomal Membrane Protein Lamp2 Alleviates …

http://www.biofeng.com/adjy/zhili/pcDNA%20Flag%20Lamp2b-HA.html TīmeklisLOCUS pcDNA Flag Lamp2b-HA 6880 bp ds-DNA circular SYN 06-AUG-2024 DEFINITION Flag tag with 3 residue spacer fused to the N-terminus of Lamp2b, a transmembrane exosomal protein. 3 residue spacer then HA tag fused to the C-terminus of Lamp2b.. ACCESSION . VERSION . KEYWORDS pcDNA Flag Lamp2b-HA … Tīmeklis2024. gada 6. sept. · HuR Lamp2b exosomes lysosome protein delivery Introduction RNA metabolism is a stepwise process, including transcription, pre-mRNA processing, mRNA export, subcellular localization, translation and degradation. Specific degradation of target mRNAs holds great importance for gene therapy. u know nothing

Addgene: Plasmids related to LAMP2

Tīmeklis利用携带软骨细胞的亲合肽（CAP）融合表达展示于外泌体膜蛋白（lamp2b）上表面作为靶向的基因工程化外泌体可实现靶向软骨细胞（图1）。与无靶向的天然外泌体相 … Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins. This … Skatīt vairāk The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C … Skatīt vairāk Lysosomes are cell organelles found in most animal cells. Their main functions center around breaking down materials and debris in the cell. Some of this is done via acid hydrolases that degrade foreign materials and have specialized autolytic functions. These … Skatīt vairāk • Cluster of differentiation Skatīt vairāk • LAMP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • PDBe-KB provides an … Skatīt vairāk LAMP2 has been specifically implicated in tumor cell metastasis. Both LAMP1 and LAMP2 have been found expressed on the surface of … Skatīt vairāk • CA77.1 • QX39 Skatīt vairāk • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and … Skatīt vairāk uknown iconTīmeklis2024. gada 24. dec. · LAMP-2B is the predominant LAMP-2 isoform expressed in human CMs. ( A) Expression of the three LAMP-2 isoforms in different types of cells was examined by RNA-seq or qPCR. RNAs from three human hearts were used for qPCR. FPKM, fragments per kilobase of exon per million reads. ( B) Immunoblotting … uknown driver chevrolet trailblazer

"Tīmeklis2024. gada 15. okt. · The deduced LAMP2B protein contains 410 amino acids, like the LAMP2A protein, but its C-terminal sequence differs in the last 11 amino acids of the luminal domain, the transmembrane domain, and the cytoplasmic tail. LAMP2B retains the lysosomal targeting signal, gly-tyr-x-x, and has the same number of potential … " - Lamp2b是什么蛋白

Lamp2b是什么蛋白

Exosome-mediated delivery of kartogenin for ... - ScienceDirect

TīmeklisSynthetic peptide corresponding to Human LAMP2B aa 350 to the C-terminus (C terminal) conjugated to keyhole limpet haemocyanin. LAMP2 has 3 distinct isoforms, … TīmeklisLAMP1：LAMP2 溶酶体相关膜蛋白1和2（LAMP1: LAMP2）是溶酶体膜的组成部分，因此构成了极佳的溶酶体标志物，以此来作为溶酶体的maker再合适不过。更多的免 …

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Tīmeklis一种基于Lamp2b的融合蛋白可用于在表面显示狂犬病病毒糖蛋白（RVG），当这些胞外体被系统地给予时，表面展示的RVG导致这些胞外体在小鼠的神经元和大脑中积聚 … Tīmeklis2024. gada 25. marts · In addition, images also showed that LAMP2B colocalization with LAMP2A is lower than expected (73.88 ± 13.09%), indicating that both LAMP2 isoforms are often segregated into different vesicles (fig. S6C). Overall, our evidence indicates that LAMP2A, but not LAMP2B, participates in the loading of proteins containing …

Tīmeklis2024. gada 1. febr. · The pEGFP-C1-RVG-Lamp2b expressing vector was kindly provided by Prof. Matthew J A Wood’ lab from University of Oxford [70]. DNA sequence encoding the glycosylation sequon (GNSTM), E7 Peptide [55] and a glycine-serine spacer were synthesized and subcloned to replace the RVG fragment by XhoI/BspeI … Tīmeklis2024. gada 21. marts · LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with LAMP2 include Danon Disease and Left Ventricular Noncompaction . Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System .

TīmeklisPlasmid pcDNA GNSTM-3-RVG-10-Lamp2b-HA from Dr. Joshua Leonard's lab contains the insert Lamp2b and is published in J Biol Chem. 2015 Mar 27;290(13):8166-72. doi: 10.1074/jbc.M114.621383. Epub 2015 Feb 5. This plasmid is … Tīmeklis2024. gada 24. dec. · Here, we demonstrate that LAMP-2B promotes autophagosome–lysosome fusion in cardiomyocytes (CMs), independently of STX17. …

Tīmeklis2015. gada 27. marts · Indeed, peptides fused to the N terminus of exosome-associated transmembrane protein Lamp2b were cleaved in samples derived from both cells and exosomes. To suppress peptide loss, we engineered targeting peptide-Lamp2b fusion proteins to include a glycosylation motif at various positions. Introduction of this …

Tīmeklis2024. gada 12. dec. · 但他们没有研究RVG-Lamp2b融合蛋白是否诱导重复给药后的适应性免疫。事实上，很可能会产生适应性免疫反应。另一个未被研究者解决的问题是，受阿尔茨海默病影响的大脑中，用于使外泌体靶向大脑的RVG的受体，即α-7-亚基乙酰胆碱受体，明显减少。这个问题在开发包含抗BACE1 siRNA的RVG-外泌体用于阿尔茨 … thomas wenn louisianaTīmeklis2016. gada 27. sept. · Exosome的靶向给药方案十分繁杂，我就稍微举几个栗子来说一下，如何根据药物的不同性质，以及不同细胞的Exosome的性质，来设计实验思路，以及更好的靶向给药。. 1. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. 思路：改造 ... u know thai menuTīmeklis2024. gada 7. febr. · Lysosomal membrane permeabilization (LMP) has recently been recognized as an important cell death pathway in various cell types. However, … u know services casper wy thomas wenn for senateTīmeklis2024. gada 15. dec. · Abstract. Huntington’s disease is an autosomal-dominant neurodegenerative disease caused by CAG expansion in exon 1 of the huntingtin (HTT) gene.Since mutant huntingtin (mHTT) protein is the root cause of Huntington’s disease, oligonucleotide-based therapeutic approaches using small interfering RNAs … uknowsup instaTīmeklis载体简介载体序列 LOCUS pcDNA GNSTM-3-RVG-10-Lamp2b-HA 6988 bp ds-DNA circular SYN 06-AUG-2024 DEFINITION Encodes (N to C): GNSTM glycosylation motif, 3 residue spacer, RVG peptide, 10 residue spacer, Lamp2b (exosomal transmembrane protein), 3 residue spacer, HA tag.. ACCESSION . VERSION . u know these songsTīmeklisAll lanes : Anti-LAMP2B antibody - Lysosome Marker (ab18529) at 1 µg/ml Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : HEK293 (Human) Whole Cell Lysate Lysates/proteins at 20 µg per lane. Secondary All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed at 1/50000 dilution Developed using … u know thai earlwood