Nucleophosmin 1
Webmammalian protein found in Homo sapiens Web13 jan. 2024 · Nucleophosmin (NPM1) is a multifunctional protein with both proliferative and growth-suppressive roles in the cell. In humans, NPM1 is involved in tumorigenesis …
Nucleophosmin 1
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NPM1 is associated with nucleolar ribonucleoprotein structures and binds single-stranded and double-stranded nucleic acids, but it binds preferentially G-quadruplex forming nucleic acids. It is involved in the biogenesis of ribosomes and may assist small basic proteins in their transport to the nucleolus. Its … Meer weergeven Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene. Meer weergeven NPM1 gene is up-regulated, mutated and chromosomally translocated in many tumor types. Chromosomal aberrations involving NPM1 were found in patients with non-Hodgkin lymphoma, acute promyelocytic leukemia, myelodysplastic syndrome, … Meer weergeven • Yun C, Wang Y, Mukhopadhyay D, Backlund P, Kolli N, Yergey A, Wilkinson KD, Dasso M (November 2008). "Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases" Meer weergeven NPM1 has been shown to interact with • AKT1, • BARD1, • BRCA1, and • nucleolin. Nucleophosmin has multiple binding partners: Meer weergeven WebNucleophosmin 1 (NPM1) is a driver gene that is mutated in 30%–35% of AMLs (3, 6). Although AMLs are often heterogeneous mixtures of different leukemic subclones ( 3 , 7 …
Web9 apr. 2024 · The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the … Web21 nov. 2014 · Nucleophosmin 1 (NPM1, also referred to as B23 or numatrin in mammals, and NO38 in amphibians) is a ubiquitously expressed nucleolar phosphoprotein and is a …
Web22 dec. 2024 · Nucleoli have viscoelastic gel-like condensate dynamics that are not well represented in vitro . Nucleoli models, such as those formed by nucleophosmin 1 … WebThe nucleophosmin-1 (NPM1) gene maps to chromosome 5q35. The cDNA has a coding sequence equivalent to a protein of 294 amino acids. Nucleophosmin is an abundant …
Web21 mrt. 2024 · NPM1 (Nucleophosmin 1) is a Protein Coding gene. Diseases associated with NPM1 include Aml With Myelodysplasia-Related Features and Leukemia, Acute …
WebDisease relevance of Npm1. Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/ Akt … driving lessons winchesterWeb8 okt. 2024 · Introduction. The nucleophosmin (NPM1) gene encodes for a ubiquitous multifunctional shuttling protein 1 with predominant nucleolar localization. NPM1 is the … driving lessons wilmslowWeb29 aug. 2024 · Nucleophosmin 1 co-expression network enrichment analysis ClusterProfiler package in R was used to analyze the above intersection of genes related … epson l120 green and orange blinking togetherWeb11 apr. 2024 · 参考：「nucleophosmin」の例文一覧. Expression of nucleophosmin has been shown to be required for proliferation of lung cancer cells. ヌクレオフォスミンの発 … epson l120 both blinking red and greenWeb12 dec. 2024 · NPM1 participates in multiple protein–protein interactions one of which involves the CCCTC-binding factor (CTCF). Through binding of CTCF binding sites (CBS), CTCF mediates nuclear functions... epson l120 end of service lifeWeb10 sep. 2024 · The NPM1 gene encodes the nucleophosmin, also known as nucleolar phosphoprotein B23 or numatrin and NO38. NPM1 is an abbreviation for … epson l120 clean printheadWeb14 apr. 2024 · Nucleophosmin 1 (NPM1) mutation is the primary genetic lesion in adult acute myeloid leukemia (AML). Typically, a nucleolar protein, NPM1 mutations cause … epson l120 blinking power and reset button