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Organic anion transporter 3

Members of the Organo Anion Transporter (OAT) Family (organic-anion-transporting polypeptides, OATP) are membrane transport proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane. Therefore, OATPs are present in the lipid bilayer of the cell membrane, acting as the cell's gatekeepers. OATPs belong to the Solute Carrier Family (SLC) and the major facilitator superfamily. Witryna10 gru 2014 · Organic anion transporter 3 inhibition increased bumetanide concentration in dialysate. To assess the extent of bumetanide transport into the brain at steady state, bumetanide was administered to all rats as an intravenous 10 mg/kg bolus followed by an infusion of 6 mg/kg/h.

Organic anion transporter 3 interacts selectively with lipophilic β ...

Witryna7 lis 2024 · 2. Transporters involved in the handling of uric acid in vivo. Uric acid possesses two ionizable groups with pKa values of 5.4 and 10.3; as such, this metabolite exists as a monovalent urate anion under physiological conditions with pH 7.4 [6,7].This ionized form is not diffusible across biological membranes; therefore, both excretion … Witryna1 sty 2015 · The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of … byk smart chart ライセンス https://neisource.com

Organic Anion Transporter 3 - an overview ScienceDirect …

Witryna15 maj 2024 · Organic anion transporter 3 (OAT3)-mediated transport of dicaffeoylquinic acids and prediction of potential drug-drug interaction. Author links … Witryna5 lip 2004 · Mediates the transport of organic anions such as estrone 3-sulfate and thyroid hormones 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4) (PubMed:14993604, PubMed:19129463). Capable of transporting pharmacological substances such as digoxin, ouabain, methotrexate and cAMP (PubMed:14993604). … http://www.bjbalb.com/html/Antigen/GH0059.html byk smart chart

SLC22A7 solute carrier family 22 member 7 [ (human)]

Category:Distribution of organic anion transporters NaDC3 and OAT1-3

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Organic anion transporter 3

Positive correlation between organic anion transporter 1B …

Cyclosporin A (CyA) has potent inhibitory activity on organic anion transporting polypeptide 1B (OATP1B), causing drug–drug interactions ... WitrynaSolute carrier organic anion transporter family member 1B3: transporter: Novobiocin: Solute carrier organic anion transporter family member 2B1: transporter: Liotrix: Thyroid hormone receptor alpha: target: Liotrix: Thyroid hormone receptor beta: target: Liotrix: Cytochrome P450 2C8: enzyme: Liotrix: Solute carrier organic anion …

Organic anion transporter 3

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Witryna14 lip 2024 · Human sodium phosphate co-transporter type 4 (NPT4/SLC17A3) is a multi-specific organic anion efflux transporter expressed in the kidneys and liver. NPT4 is located at the apical side of renal tubules, and functions as an apical voltage-driven urate efflux transporter, also known as NPT4-Na + /phosphate co-transporter … WitrynaThe organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. [2] [3] [4] …

Witryna有机阴离子转运蛋白3(Organic Anion Transporter 3,OAT3)是由536个氨基酸组成的跨膜转运蛋白，与rOAT1、rOAT2分别有49％、39％的同源性。人OAT3的基因位于llql1.7，含有12个跨膜结构域，4个N一糖基化位点,8个依赖蛋白激酶C的磷酸化位点，也参与尿酸盐 … Witryna27 lut 2024 · The anion exchange (AIX) spent brine, generated during the NDMP-3 resin regeneration process, highly loaded with organic substances mainly humic substances (HSs) and salts (mainly NaCl) remains an environmental concern. In this study, pilot-scale electro dialysis (ED) and ultrafiltration (UF) hybrid technologies were first used …

WitrynaBeneficial herb-drug interaction of rhein in Jinhongtang and Imipenem/Cilastatin mediated by organic anion transporters J Ethnopharmacol. 2024 Apr 4 ... 3 Second Affiliated Hospital, Institute of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, 116023, China. Electronic address: [email protected]. WitrynaOrganic anion transporter 3 (OAT3) plays a significant role in the uptake of methotrexate into the renal proximal tubule cells. Therefore, inhibitors of organic …

Witryna9 lip 2024 · Organic anion transporting polypeptides (OATPs) are important transporter proteins that are expressed at the plasma membrane of cells, where they mediate the influx of endogenous and exogenous substances including hormones, natural compounds and many clinically important drugs. OATP1A2, OATP2B1, OATP1B1 …

Witryna5 paź 2010 · Function. ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates … byk spectro2guideWitryna1 lip 2016 · The initial step in renal secretion of organic anions (OAs) is mediated by transporters in the basolateral membrane (BLM). Contributors to this process are … byk spectro2profilerWitryna byk starting formulationsWitryna31. Takeda, M., et al., Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. Eur J Pharmacol, 2001. 419(2 … byk spectrophotometerWitryna16 maj 2024 · Some helpful insights regarding nephrotoxicity potential of different β-lactams when combined with vancomycin can be made when reviewing the study by … byk spectro-guide sphere glossWitryna10 sty 2003 · Mediates the Na +-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, taurocholate, estrone 3-sulfate, estradiol-17beta-glucuronide and prostaglandin E2 (PGE2) (PubMed:10873595, PubMed:19129463). Shows a pH-sensitive substrate specificity … byk spectrometerWitrynaView/Edit Mouse. Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) … byk surfactants